Gareth Anscombe has edged out Dan Biggar for the Wales outside-half spot for Saturday’s crunch meeting with England in Cardiff.
Anscombe returns to the side at No 10 having started the opener against France with Biggar dropping back to the bench having started the last game against Italy.
Wales coach Warren Gatland has also recalled Gareth Davies to partner Anscombe while Dragons lock Cory Hill gets the nod at lock from Adam Beard.
Hill will pack down alongside skipper Alun Wyn Jones who returns to the side after being rested against Italy to make his 122nd Welsh appearance, his 21st as captain.
“We are really happy with the experience we have got in the side,” said Wales head coach Warren Gatland. “We have been on the road for the first two weeks, we are looking forward to being back at home and to build on those first two wins and to build on our performance.
“We’ve had a great two-week lead up to this game, we’ve looked really sharp and the squad are incredibly motivated to kick on.
“We know how important this game is for the rest of the championship. It’s a massive challenge playing against an England team that is playing really well and with a lot of confidence and we’ve got to make it difficult for them on Saturday.
“We are looking forward to it and we know the Welsh fans are too and it’s going to be a huge weekend in the Six Nations.”
Josh Navidi, Justin Tipuric and Ross Moriarty forming the back-row. A front-row of Rob Evans, Ken Owens and Tomas Francis complete the forwards line-up.
Hadleigh Parkes and Jonathan Davies will partner again in the midfield. Josh Adams, George North and Liam Williams make up the back-three.
Elliot Dee, Nicky Smith and Dillon Lewis provide Wales’ front-row replacements with Adam Beard and Aaron Wainwright completing the forward contingent. Aled Davies, Dan Biggar and Owen Watkin provide the backline cover.
Wales: Liam Williams (Saracens); George North (Ospreys), Jonathan Davies (Scarlets), Hadleigh Parkes (Scarlets), Josh Adams (Worcester); Gareth Anscombe (Cardiff Blues), Gareth Davies (Scarlets); Rob Evans (Scarlets), Ken Owens (Scarlets), Tomas Francis (Exeter), Cory Hill (Dragons), Alun Wyn Jones (Ospreys, captain), Josh Navidi (Cardiff Blues), Justin Tipuric (Ospreys), Ross Moriarty (Dragons).
Replacements: Elliot Dee (Dragons), Nicky Smith (Ospreys), Dillon Lewis (Cardiff Blues), Adam Beard (Ospreys), Aaron Wainwright (Dragons), Aled Davies (Ospreys), Dan Biggar (Northampton), Owen Watkin (Ospreys).